4/6/2023 0 Comments Spirou![]() Coordination of neural circuit formation by extrinsic factors, such as vascular expansion and myelination.Factors that initiate rapid calyx growth and synapse formation early in development.The CH is the largest mammalian nerve terminal and represents a powerful developmental model for studying synaptic formation and strengthening.Ī few (of many) open questions addressed by the ADCL: The ADCL approaches this topic in a unified manner and utilizes innervation of the medial nucleus of the trapezoid body (MNTB) by the calyx of Held (CH) nerve terminal as a model. These events are coordinated by a multitude of intrinsic and extrinsic factors, which are not well-understood as an integrated process with cellular physiology and anatomy. Neural circuit formation is an under-appreciated complete transformation of tissue structure, involving axon extension, the formation of exuberant neural connections, pruning of supernumerary inputs, glial cell proliferation and maturation, and vascular remodeling. ![]()
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